DRIVERS OF CKD PROGRESSION

CKD PROGRESSION IN T2D IS INFLUENCED BY
3 MAJOR CATEGORIES OF DRIVERS1,2

Metabolic driver of CKD

Metabolic Drivers

  • Elevated blood glucose (HbA1c) levels

Hemodynamic driver of CKD

Hemodynamic Drivers

  • Elevated blood pressure (BP)
  • High intraglomerular pressure
 
Inflammatory and fibrotic drivers

Inflammatory and Fibrotic Drivers

  • Presence and/or release of proinflammatory proteins and profibrotic proteins

CKD Progression

CKD: chronic kidney disease; T2D: type 2 diabetes.

Inflammatory and fibrotic drivers in the kidneys are largely unaddressed in patients with CKD and T2D1

HbA1c AND BP CONTROL AREN’T ALWAYS ENOUGH3-5

Today, physicians are fighting CKD in T2D on multiple fronts. But even with well-controlled HbA1c and BP, many patients with CKD and T2D are still experiencing CKD progression. While modest gains have been made due to advancements in the field, there are more opportunities to reduce the residual risk of4-7:

  • End-stage kidney disease (ESKD)
  • Death from renal disease
CKD Progression Image

Patients with controlled BP still have a significant risk of ESKD or death.6

Intensive-a1c image

Intensive HbA1c control has only a modest impact on progression to ESKD4,5

Learn more about inflammation and fibrosis
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Watch how inflammation and fibrosis are triggered by MR overactivation
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MR: mineralocorticoid receptor.

References: