EARLY DIAGNOSIS

ELEVATED UACR LEVELS: AN EARLY MARKER FOR INCREASED CV RISK AND CKD PROGRESSION1

DELAYS TO DIAGNOSIS OF CKD CAN HAVE DEVASTATING CONSEQUENCES FOR PATIENTS WITH T2D, SUCH AS EARLY DEATH FROM CV CAUSES OR THE NEED FOR DIALYSIS OR KIDNEY TRANSPLANT1,2

UACR testing

UACR screening is the gold-standard method above dipstick testing, enabling detection of albuminuria, an early marker for CV risk and CKD progression1

UACR elevation

Even patients with normal eGFR are at increased risk of CV events and CKD progression if UACR levels are elevated1,3

Albuminuria measurement

Relying on eGFR alone may cause early signs of CKD in T2D to be missed, which can be detected by complementary measurement of albuminuria via UACR tests1,2,4

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See what medical guidelines recommend for early diagnosis and CV risk assessment in CKD in T2D
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CKD=chronic kidney disease; CV=cardiovascular; eGFR=estimated glomerular filtration rate; T2D=type 2 diabetes; UACR=urine albumin-to-creatinine ratio.

References:

  • Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. Kidney Int Suppl. 2013;3(1):1–150. Return to content
  • American Diabetes Association Professional Practice Committee. Diabetes Care. 2022;45(suppl 1): S1–S264. Return to content
  • Levey AS, et al. Kidney Int. 2011;80(1):17-28. Return to content
  • Campion CG, et al. Can J Kidney Health Dis. 2017;4. doi:10.1177/2054358117705371. Return to content

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Last updated in June 2022

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