MR overactivation may lead to inflammation and fibrosis, thus contributing to damage in the kidneys and CV system.1-5
Inflammation and fibrosis in CKD and T2D as driven by MR overactivation video
Rajiv Agarwal, MD, takes us through how MR overactivation impacts inflammation and fibrosis and leads to CKD progression and CV events1-5
MR overactivation contributes to the risk of CV dysfunction4,6
Both preclinical and clinical trials provide evidence of the connection between MR overactivation and CV dysfunction. As CKD progresses, there is an increased chance that a patient with CKD and T2D might experience a CV event like a myocardial infarction or stroke.
Read more about the effects of MR overactivation on a cellular level
Together, these effects elevate the risk of CKD progression and cardiovascular events.11
BP=blood pressure; CKD=chronic kidney disease; CV=cardiovascular; MR=mineralocorticoid receptor; T2D=type 2 diabetes; UACR=urine albumin-to-creatinine ratio.