Inflammation and fibrosis are a major driver of CKD progression in patients with T2D. Triggered by MR overactivation, inflammation and fibrosis may cause irrevocable kidney damage.1-4
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MR overactivation can trigger the production of proinflammatory and profibrotic proteins, which may lead to kidney damage1,2
Inflammation and fibrosis in CKD and T2D as driven by MR overactivation video
Rajiv Agarwal, MD, takes us through how MR overactivation impacts inflammation and fibrosis and leads to CKD progression
Cells within the glomerulus (a tuft of capillaries that remove waste from blood) proliferate and expand, resulting in mesangial matrix expansion. There is a strong link between this process and CKD progression.5
Thickening and scarring in and around the renal tubules can decrease renal function and increase pressure.5
The hardening and scarring of the glomerulus lead to an excessive loss of protein.5
Structural damage to the kidney impairs the organ’s functionality.5
In the kidney, inflammation and fibrosis can lead to tissue expansion, increased pressure within the vasculature and internal structure, and eventually scarring that makes effective filtration increasingly difficult.2
CKD: chronic kidney disease; CV: cardiovascular; MR: mineralocorticoid receptor; T2D: type 2 diabetes.